Calcifediol (INN), also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase which was isolated by Michael F. Holick. Physicians worldwide measure this metabolite to determine a patient's vitamin D status. At a typical daily intake of vitamin D3, its full conversion to calcifediol takes approximately 7 days.

Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation.

基本信息

中文名称：骨化二醇

中文别名： 25-羟基维生素D3;

骨化三醇;

骨化二醇;

英文名称：calcidiol

英文别名： 25-Hydroxycholecalciferol;

Calcifediol;

Calcidiol,Didrogyl,Hidroferol;

Vitamin D3 25 Calcifediol;

Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol;

25-Hydroxyvitamin D3;

CAS号：19356-17-3

分子式：C27H44O2

分子量：400.63700

精确质量：400.33400

PSA：40.46000

LogP：6.73390

物化性质

密度：1.01 g/cm3

沸点：529.2ºC at 760 mmHg

闪点：221.4ºC

储存条件：-20ºC

安全信息

危险品标志：T+

WGK Germany：3

安全说明：28-36/37-45

危险品运输编码：UN 2811 6

危险类别码：R28