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丝裂霉素C
存储条件：
英文名：Mitomycin C
CAS号：50-07-7
产品别名：嘧吡霉素; 密吐霉素; 丝裂霉素C; 自力霉素; 突变霉素[1ar-(1aalpha,8beta,8aalpha,8balpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-alpha]indole-4,7-dione; 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate (ester); AMETYCIN; MITOCIN C; MITOMYCIN; MITOMYCIN C; MITOMYCIN C, STREPTOMYCES CAESPITOSUS; MMC; MUTAMYCIN; )methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,; 7-amino-9-alpha-methoxymitosane; 8aalpha,8balpha))-(9ci); 8balpha)]-8aalph; azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy; azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy; azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox; mitomycinum; mitomycynac; mitomycynac(polish) show
   
英文名：Mitomycin C
存储条件：
CAS号：50-07-7
产品别名：嘧吡霉素; 密吐霉素; 丝裂霉素C; 自力霉素; 突变霉素[1ar-(1aalpha,8beta,8aalpha,8balpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-alpha]indole-4,7-dione; 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate (ester); AMETYCIN; MITOCIN C; MITOMYCIN; MITOMYCIN C; MITOMYCIN C, STREPTOMYCES CAESPITOSUS; MMC; MUTAMYCIN; )methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,; 7-amino-9-alpha-methoxymitosane; 8aalpha,8balpha))-(9ci); 8balpha)]-8aalph; azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy; azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy; azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox; mitomycinum; mitomycynac; mitomycynac(polish)

产品编号 M0503 | CAS号 50-07-7 | SIGMA

丝裂霉素 C 来源于头状链霉菌


Mitomycin C from Streptomyces caespitosus

powder, contains NaCl as solubilizer

安全技术说明书

  • 经验分子式（希尔表示法） C15H18N4O5

     

  • 分子量 334.33

     

  •  Beilstein Registry Number 7231816

  •  MDL number MFCD00078109

     

  •  PubChem Substance ID 24896555

  • POPULAR DOCUMENTS:  PRODUCT INFORMATION SHEET (PDF)  |  SPECIFICATION SHEET (PDF)

    产品描述

    Application

    Mitomycin C is produced by a strain of actinomyces, Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

    Biochem/physiol Actions

    DNA 合成、细胞核分裂和癌细胞的抑制剂。对革兰氏阳性菌、革兰氏阴性菌、抗酸杆菌有抗菌性。

    Caution

    This vial contains 2 mg Mitomycin C and 48 mg NaCl. Stock solutions should be filter sterilized and stored at 2-8°C in the dark. Solutions at pH 6-9 can be stored at 0-5°C for up to a week, but if a precipitate forms, a fresh solution should be prepared - the precipitated solution has been proven toxic to cells.

    Preparation Note

    Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.

    General description

    Chemical structure: aziridine

     

    性质

    Related Categories Antibiotics, Antibiotics A to Z, Antibiotics G-M, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
    更多...
    biological source   Streptomyces caespitosus
    InChI Key   NWIBSHFKIJFRCO-WUDYKRTCSA-N
    form   powder
    contains   NaCl as solubilizer
    color   gray
      purple/blue
        (1) 3.2, (2) 6.5
    solubility   H2O: 1 vial + 4 mL, clear to slightly hazy, blue to purple
    Mode of action   DNA synthesis | interferes
    antibiotic activity spectrum   Gram-negative bacteria
      Gram-positive bacteria
    storage temp.   2-8°C

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