产品编号 P8139 | CAS号 16561-29-8 | SIGMA

Phorbol 12-myristate 13-acetate

≥99% (TLC), film or powder

安全技术说明书

别名: 12-O-Tetradecanoylphorbol 13-acetate 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate PMA TPA

• 经验分子式（希尔表示法） C₃₆H₅₆O₈

   

• 分子量 616.83

   

•  Beilstein Registry Number 2407201

•  MDL number MFCD00036736

   

•  PubChem Substance ID 24278653

• POPULAR DOCUMENTS:  PRODUCT INFORMATION SHEET (PDF)  |  SPECIFICATION SHEET (PDF)

  产品描述

  Biochem/physiol Actions

  Potent tumor promoter; activates protein kinase C in vivo and in vitro.

  Caution

  Photosensitive

  Application

  Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent lymphocytes and fetal thymocytes.^[2][3][4] It has also been used for the activation of PKC (protein kinase C) in cells.^[5]

  Features and Benefits

  This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC^®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

  This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

  General description

  Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC) signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and cytokines-mediated regulation of cellular growth and differentiation.^[1]

  法律信息

  LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

   

  性质

  Related Categories	Bioactive Small Molecule Alphabetical Index,Euphorbia sp, Kinase/Phosphatase Biology, P-PH,Phytochemicals by Plant (Food/Spice/Herb), 更多...
  InChI Key	PHEDXBVPIONUQT-RGYGYFBISA-N
  assay	≥99% (TLC)
  form	film or powder
  solubility	DMSO: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.)
  	ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)
  storage temp.	−20°C

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